“Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature, such as self-preservation?”
Memo dated January 1952

Project ARTICHOKE (also referred to as Operation ARTICHOKE) was a mind control program that gathered information together with the intelligence divisions of the Army, Navy, Air Force, and FBI. ARTICHOKE was conducted and coordinated by the Central Intelligence Agency (CIA) to research interrogation methods. Preceded by Project BLUEBIRD, ARTICHOKE officially arose on August 20, 1951 and was operated by the CIA's Office of Scientific Intelligence.

The primary goal of Project ARTICHOKE was to determine whether a person could be involuntarily made to perform an act of attempted assassination. The project also studied hypnosis, forced morphine addiction (and subsequent forced withdrawal), and the use of other chemicals including LSD, to produce amnesia and other vulnerable states in subjects.

Project ARTICHOKE was the Central Intelligence Agency's secret code name for carrying out in-house and overseas experiments using LSD, hypnosis, and total isolation as a form of physiological harassment for special interrogations on human subjects. At first agents used cocaine, marijuana, heroin, peyote, and mescaline, but they increasingly saw LSD as the most promising drug. The subjects who left this project were fogged with amnesia (how?), resulting in faulty and vague memories of the experience. In 1952, LSD was increasingly given to unknowing CIA agents to determine the drug's effects on unsuspecting people. One record states an agent was kept on LSD for 77 days.

ARTICHOKE researched the potential of dengue fever and other diseases. A declassified ARTICHOKE memo read: “Not all viruses have to be lethal… the objective includes those that act as short-term and long-term incapacitating agents.”

The CIA disputed which department would take over the operation. Finally, it was decided that an agent from the CIA research staff, former United States Army brigadier general Paul F. Gaynor, would oversee it. The CIA sought to establish control over what it perceived as the “weaker“ and “less intelligent” segments of society, or for potential agents, defectors, refugees, POWs and others. A CIA report states that if hypnosis succeeded, assassins could be created to assassinate "a prominent [redacted] politician or if necessary, [an] American official." The overseas operations took place in locations throughout Europe, Japan, Southeast Asia, and the Philippines. Teams were assembled to manage these operations, and they were told to "conduct at the overseas bases operational experiments utilizing aliens as subjects."

Project ARTICHOKE led to Project MKUltra, which began in 1953.

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